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Constipated by opioid
pain medicine?

Find out more

Learn more about Opioid-Induced Constipation (OIC)

 

On opioid pain medications for chronic pain?

See some examples
 

Constipated?

Symptoms of OIC
 

Feel you tried it all?

See why routine constipation treatments may not work for everyone with OIC

Opioid-Induced Constipation (OIC) is a Unique Type of Constipation

Opioid treatment can help relieve moderate to severe pain. Unfortunately, opioid use often comes with the undesired effect of constipation. If you’re taking opioid pain medicine and experiencing difficulty with bowel movements, you may have OIC.

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Like other OIC sufferers, you may have already tried over-the-counter laxatives, diet changes, and exercise.
The truth is, OIC is a unique type of constipation that may require a specific kind of treatment.

Learn more

Check Relistor

Relistor is specifically designed to target the constipating effect opioids have in the gut.

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  • May increase the number of spontaneous bowel movements.*

  • May cause a bowel movement within 4 hours*

  • Available in two formulations for the treatment of OIC in long-lasting (chronic) non-cancer pain patients

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*Individual results may vary
Based on a clinical study of 401 adult patients with opioid-induced constipation (OIC) and long-lasting (chronic) non-cancer pain treated with RELISTOR tablets or placebo (sugar pill).

Based on a clinical study of 312 adult patients with OIC and long-lasting (chronic) non-cancer pain treated with RELISTOR injection or placebo injection.

The only OIC prescription treatment with two formulations

Talk to your healthcare provider about which option is best for you.

Tablets

For adult patients with long-lasting (chronic) non-cancer pain.
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tablet bottle
For adult patients with long-lasting (chronic) non-cancer pain.
logo tablet

subcutaneous Injection

For adult patients with advanced illness or pain cause by active cancer and who need increases in their opioid dose for comfort care.
For adult patients with long-lasting (chronic) non-cancer pain.
logo tablet
injection
For adult patients with advanced illness or pain cause by active cancer and who need increases in their opioid dose for comfort care.
For adult patients with long-lasting (chronic) non-cancer pain.
logo tablet

How Relistor works

RELISTOR works differently from over-the-counter (OTC) laxatives. It’s an FDA-approved prescription medication for opioid-induced constipation specifically designed to target the constipating effect opioids have in the gut, without impacting opioid pain relief in the central nervous system. Tell your doctor if you experience any changes in your pain relief.
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Opioids relieve pain by attaching to mu-opioid receptors in the central nervous system.
Opioids attach to mu-opioid receptors in your bowels. This can cause constipation.
Relistor can help keep opioids from attaching to mu-opioid receptors in the gut, decreasing the constipating effects.

In 2020, 89% of eligible commercial patients that filled their prescription and used the copay card paid $0.

Learn more Terms and conditions apply. Click here for details.

Eligible patients may pay as little as $0 with a co-pay card

copay coupon Terms and conditions apply. Click here for details.
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talk to your doctor

Challenge OIC

Talk about your symptoms with your healthcare provider to find out how Relistor can help manage your OIC.

Download the Healthcare Provider Discussion Guide
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Check in with your gut.
Check RELISTOR

Indications

RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

Important Safety Information

  • Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.
  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.

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Indications - RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

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Important Safety Information - Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.

plus icon

Indications

RELISTOR® is a prescription medicine used to treat constipation in adults that is caused by prescription pain medicines called opioids.

  • RELISTOR tablets and RELISTOR injection are used to treat constipation caused by opioids in adults with long-lasting (chronic) pain that is not caused by active cancer.
  • RELISTOR injection is also used to treat constipation caused by opioids in adults with advanced illness or pain caused by active cancer and who need increases in their opioid dose for comfort care.

It is not known if RELISTOR is safe and effective in children.

Important Safety Information

Do not take Relistor if you have a bowel blockage (called an intestinal obstruction) or have a history of bowel blockage.

  • Relistor can cause serious side effects such as a tear in your stomach or intestinal wall (perforation). Stomach pain that is severe can be a sign of a serious medical condition. If you get stomach pain that is severe, does not go away, or gets worse, stop taking Relistor and get emergency medical help right away.
  • Stop using Relistor and call your healthcare provider if you get diarrhea that is severe or that does not go away during treatment with Relistor.
  • You may have symptoms of opioid withdrawal during treatment with Relistor including sweating, chills, diarrhea, stomach pain, anxiety, and yawning. Tell your healthcare provider if you have any of these symptoms.
  • Tell your healthcare provider if you have kidney or liver problems.
  • Tell your healthcare provider if you have any stomach or bowel (intestines) problems, including stomach ulcer, Crohn’s disease, diverticulitis, cancer of the stomach or bowel, or Ogilvie’s syndrome.
  • Tell your healthcare provider if you are pregnant or plan to become pregnant. Taking Relistor during pregnancy may cause opioid withdrawal symptoms in your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with Relistor.
  • Taking Relistor while you are breastfeeding may cause opioid withdrawal in your baby. You should not breastfeed during treatment with Relistor. You and your healthcare provider should decide if you will take Relistor or breastfeed. You should not do both.
  • Also, tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
  • In a clinical study, the most common side effects of Relistor tablets in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, diarrhea, headache, swelling or a feeling of fullness or pressure in your abdomen, sweating, anxiety, muscle spasms, runny nose, and chills.
  • In a clinical study, the most common side effects of Relistor injection in people with long-lasting (chronic) pain that is not caused by cancer include: stomach-area (abdomen) pain, nausea, diarrhea, sweating, hot flush, tremor, and chills.
  • In clinical studies, the most common side effects of Relistor injection in people receiving treatment for their advanced illness include: stomach-area (abdomen) pain, gas, nausea, dizziness, and diarrhea.

You are encouraged to report side effects of prescription drugs to FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For product information, adverse event reports, and product complaint reports, please contact:

Salix Product Information Call Center
Phone: 1-800-321-4576
Fax: 1-510-595-8183

Please click here for full Prescribing Information for RELISTOR tablets and RELISTOR injection, including medication guide.